![]() This drug binds to β-tubulin to inhibit the disassembly of microtubules, thus inhibiting cell replication and inducing apoptosis. With cessation of docetaxel therapy and treatment with systemic corticosteroids, visual recovery can occur without significant residual visual deficit.ĭocetaxel is an anticancer cytotoxic that belongs to the taxane family. Conclusionĭocetaxel can cause a toxic optic neuropathy possibly due to an ischemic or neurotoxic mechanism at the optic nerve head. Docetaxel chemotherapy was discontinued but targeted therapy with trastuzumab continued without further complication. Visual field defects gradually resolved and visual acuity improved. She was treated with high dose corticosteroids intravenously for 1 week then a tapering oral dose over 8 weeks. Extensive investigation ruled out other causes of optic neuropathy. ![]() Case presentationĪ 53-year-old female presented with predominantly unilateral visual loss, but extensive bilateral visual field defects and bilateral optic nerve head swelling 2 weeks after first dose of docetaxel (Taxotere®) and trastuzumab (Herceptin®) chemotherapy for a left sided node-positive, HER2 positive breast cancer. To describe the first reported case of toxic optic neuropathy secondary to docetaxel (Taxotere®) chemotherapy.
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